BackgroundSexual minority (SM) older adults experience mental health disparities. Psychiatric disorders and neuropsychiatric symptoms (NPS) are risk factors for cognitive decline. Although older people in same-sex (SSR) compared to mixed-sex relationships (MSR) perform more poorly on cognitive screening tests, prior studies found no differences in rates of dementia diagnosis or neuropsychological profiles. We sought to explore the role of NPS on neurocognitive outcomes for SM populations. We compared cognitive performance and structural brain parameters of older adults in SSR and MSR.MethodsData (...) were originally collected at Alzheimer's Disease Research Centers (ADRCs). Inclusion criteria were: age of 55+ years, a study partner identified as a spouse/partner, and availability of T1-MRI brain volumes/thickness. Participants were labeled as either SSR or MSR based on their/their co-participant's reported sex. We identified 1,073 participants (1,037 MSR−555 cognitively unimpaired [CU]; 36 SSR−23 CU) with structural MRI data, Mini-Mental State Exam (MMSE), and Neuropsychiatric Inventory Questionnaire (NPI-Q) scores. A subset of the overall sample completed comprehensive neuropsychological assessment (n = 939; 908 MSR−494 CU; 31 SSR−22 CU). Covariates included in statistical models were age, sex, education, total intracranial volume, and apolipoprotein E genotype.ResultsMultivariate general linear models showed significant diagnosis-by-relationship interaction effects on the left parahippocampal gyrus volume. After stratification by relationship group, only cognitively impaired (CI) MSR had significantly smaller left parahippocampal volumes than MSR-CU. The SSR group showed better episodic memory performance. Severity of neuropsychiatric symptoms was negatively associated with volume/thickness of bilateral fronto-temporal areas and with MMSE scores, predominantly in the MSR group.ConclusionIn our study, MSR participants presented with a more compromised cognitive profile than SSR participants. MSR-CI participants showed significantly smaller left medio-temporal volumes, a neural signature of AD. Neuropsychiatric symptoms predicted smaller fronto-temporal volumes in the MSR more consistently than in the SSR group. These findings may be due to unexplored protective factors against cognitive decline in SM elders. Indeed, social support has been proposed as a protective factor warranting future investigation. (shrink)

The structure of traditional fiction is essentially linear or serial. No matter how complex a given work may be, it presents information to its reader successively, one element at a time, in a sequence determined by its author. By contrast, interactive fiction is parallel in structure or, more accurately, dendritic or tree-shaped. Not one, but several possible courses of action are open to the reader. Further, which one actually happens depends largely, though not exclusively, upon the reader’s own choices. To (...) be sure, the author is still in overall control, since it is she who has set up the particular nexus of events, but the route up the narrative tree, the actual sequence of events, is generally affected, if not completely determined, by the reader’s responses to that particular reader’s specific situation. In an adventure, the sequence of action frequently depends upon the reader’s decision to go in one geographical direction rather than another. In the eliza sample, the content of the “story” depends on such particulars as whether this reader has a brother or not, whether she fears her father, and why she has consulted the terminal. In general, the text presented to the eliza-reader depends on what that reader has already said and how the computer has interpreted and stored it, and this is generally true of interactive fiction.Further, interactive fiction is, in principle , open-ended—infinite. A conversation with eliza could go on for as long as one with Woody Allen’s psychoanalyst—in principle, forever. It has no necessary terminus. The program will go one writing texts and answers on the screen as long as the reader or player chooses to supply responses. Further, the computer can act as a metafictional narrator like John Barth or Thomas Pynchon who can create a story within a story or a story that generates another story within itself which generates another story within itself and so on, fictions dizzying and dazzling. One senses one’s essential humanity wobbling in the midst of the infinite paradoxes of existence and meaning. Anthony J. Niesz, assistant professor of German at Yale University, is the author of Dramaturgy in German Drama: From Gryphius to Goethe . He is interested in the phenomenon of the meta-theater, especially in seventeenth- and eighteenth-century German drama, as well as in the literature and cultural policies of the German Democratic Republic. Norman N. Holland is Milbauer Eminent Scholar at the University of Florida. He is the author of Laughing and The I. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Narrative Symposium:Conflicting Interests in MedicineLaura Jean Bierut, Sal Cruz-Flores, Laura E. Hodges, Anthony A. Mikulec, Govind K. Nagaldinne, Erine L. Bakanas, John F. Peppin, Joel S. Perlmutter, William H. Seitz Jr., Edward Diao, Andre N. Sofair, and David M. Zientek• To Recruit or Not to Recruit for a Clinical Trial• An Unexpected Lesson• Am I on call for the entire Midwest?• Why is Medicare Wasting Away?• The Downside (...) of the Informed Consent Juggernaut• Expert Testimony at the Food and Drug Administration: Who Wants the Truth?• Crossroads: The Intersection of Personal, Professional Society, and Industry Relationships• A Change of Heart• The Evolution of Conflicts of Interest in a New Subspecialty: A Case Study of the Development of Interventional CardiologyCopyright © 2011 The Johns Hopkins University Press... (shrink)

BackgroundBurnout is being experienced by medical students, residents, and practicing physicians at significant rates. Higher levels of Hardiness and Emotional Intelligence may protect individuals against burnout symptoms. Previous studies have shown both Hardiness and Emotional IntelIigence protect against detrimental effects of stress and can be adapted through training; however, there is limited research on how training programs affect both simultaneously. Therefore, the objective of this study was to define the association of Hardiness and Emotional Intelligence and their potential improvement through (...) hyper realistic immersion simulation training in military medical students.MethodsParticipants in this study consisted of 68 second year medical students representing five medical schools who were concurrently enrolled in the United States military scholarship program. During a six day hyper-realistic surgical simulation training course, students rotated through different roles of a medical team and responded to several mass-casualty scenarios. Hardiness and Emotional Intelligence were assessed using the Hardiness Resilience Gauge (HRG) and the Emotional Quotient Inventory (EQ-I 2.0) respectively, at two time points: on arrival (pre-event) and after completion of the course (post-event).ResultsHardiness and Emotional Intelligence scores and sub scores consistently improved from pre-event to post-event assessments. No difference in training benefit was observed between genders but differences were observed by age where age was more often associated with Emotional Intelligence. In addition, factor analysis indicated that the HRG and EQ-I 2.0 assessment tools measured predominately different traits although they share some commonalities in some components.ConclusionThis study indicates that Hardiness and Emotional Intelligence scores can be improved through immersion training in military medical students. Results from this study support the use of training course interventions and prompt the need for long term evaluation of improvement strategies on mitigating burnout symptoms. (shrink)

Shah, N. The Philosophical Quarterly, 56, 481–498 (2006) has defended evidentialism on the premise that only it (and not pragmatism) is consistent with both (a) the deliberative constraint on reasons and (b) the transparency feature of belief. I show, however, that the deliberative constraint on reasons is also problematic for evidentialism. I also suggest a way for pragmatism to be construed so as to make it consistent with both (a) and (b) and argue that a similar move is not available (...) to the evidentialist. Thus, far from settling the debate in favour of evidentialism, considerations concerning the deliberative constraint on reasons support pragmatism. (shrink)

This paper pr o vides an o v e r vi e w of the themes presented in Bentha m ' s w ork Scotch Reform -a n e w w ork being prepared for pu b lication from Bentha m ' s manuscripts b y Oxford Un i v ersity Press as pa r t of the Collected Works of Jeremy Bentham. Attention is focused on the relationship bet w een the system of l e g al procedure proposed (...) and the under l ying principle of utili t y . T w o issues are highlighte d , the nature of Bentha m ' s anti-nomian thesis for c i vil cou r ts and the parad o x of requiring restraint on the judicial control of c i vil procedure, w hilst simultaneous l y rem o ving all r ules of action and all o wing increased judicial discretion. (shrink)

Sartre draws a sharp distinction between consciousness, on the one hand, and inner sense or knowledge of (it)self, on the other: ‘La conscience n’est pas un mode de connaisance particullier, appelé sens intime ou connaisance de soi’ (B& N: 7). I explore in detail the meaning of the terms involved in that distinction with a view to highlight its significance.

Shah, N. The Philosophical Quarterly, 56, 481–498 (2006) has defended evidentialism on the premise that only it (and not pragmatism) is consistent with both (a) the deliberative constraint on reasons and (b) the transparency feature of belief. I show, however, that the deliberative constraint on reasons is also problematic for evidentialism. I also suggest a way for pragmatism to be construed so as to make it consistent with both (a) and (b) and argue that a similar move is not available (...) to the evidentialist. Thus, far from settling the debate in favour of evidentialism, considerations concerning the deliberative constraint on reasons support pragmatism. (shrink)

Although accounts of evolutionary altruism which leave the question of whether altruism can evolve in nature open to empirical confirmation/refutation have been worked out for special (two-trait) cases, no real effort has been made to work out such accounts for general (N-trait) cases. It is tempting to take this lack of attention as evidence for an inextricably conventional element, which precludes such accounts from being of practical scientific value. I argue that such accounts do generalize in a natural way. As (...) is often the case in science, generalizing theoretically simplified notions is not straightforward because of issues hidden in the special case. These issues do not, however, turn out to be essentially conventional. (shrink)

We investigated the definition, prevalence, perceived prevalence and severity of, as well as justifications for and expected responses to, academic dishonesty at the graduate level in a sample of 246 graduate students, 49 faculty, and 20 administrators. Between 2.5% and 55.1% of students self-reported engaging in academically dishonest behaviors, depending on the nature of the behavior. Students and faculty rated 40 examples of academically dishonest behaviors similarly in terms of severity, but faculty tended to underestimate the prevalence of academic dishonesty. (...) Students and faculty also reported how they would idealistically and realistically expect themselves to respond to cheating situations. Students rated 21 behaviors in terms of their likeliness to increase or decrease academically dishonest behavior. Suggestions are given for developing a climate or culture of academic integrity to address academic dishonesty. (shrink)

"Biograficheskiĭ slovarʹ russkikh filosofov"--Tom 3, pages 488-639.

In 2004, I explained the absurdity of Moore-paradoxical belief via the syllogism (Williams 2004): (1) All circumstances that justify me in believing that p are circumstances that tend to make me believe that p. (2) All circumstances that tend to make me believe that p are circumstances that justify me in believing that I believe that p. (3) All circumstances that justify me in believing that p are circumstances that justify me in believing that I believe that p. I then (...) took (3) to mean (EP) Whatever justifies me in believing that p justifies me in believing that I believe that p.1 Now suppose that I am justified in believing anything of the omissive Mooreparadoxical form: (Om) p and I do not believe that p. Then I am justified in believing the first conjunct. So by (EP) I am justified in believing that I believe that p. But since I am also justified in believing the second conjunct, I am justified in believing that I do not believe that p. I claimed that this is impossible, because anything that justifies me in believing that something is the case renders me unjustified in believing that it is not the case. This syllogism is plausible from an externalist view of justification, according to which circumstances such as seeming to see rain under normal perceptual conditions, justify me in believing that it is raining. In support of (1), if my apparent perceptions of rain are reliably connected with rain, so as to justify me in thinking that it is raining, they also tend to make me believe that it is raining. In support of (2), my apparent perceptions of rain are also reliably connected with my coming to believe that it is raining. However, Anthony Brueckner (2006) argues that (1) and (EP) are both false once justification is thought of evidentially. Against (EP), he claims that my evidence that p is not evidence that I believe that p unless I possess the evidence, in the sense that I believe it and were I to believe that p on its basis. (shrink)

Japan is a country largely lacking supplies of many essential natural resources including petroleum, coal, and iron ore. As her industrial base and economy expanded during the 1920s and 1930s, Japan's dependence on imports of these resources became increasingly evident. The onset of the Depression in the 1930s further threatened Japan's lifeline, and, in an effort to become economically independent and self-sufficient in natural resources , Japan's militaristic government pursued a policy of territorial expansion. Beginning in 1937, Japan's military forces (...) swept out of Manchuria into China and then into Southeast Asia in search of strategic materials such as petroleum, coal, copper, zinc, and rubber. To achieve independence in petroleum, the Japanese developed a dual approach: they would acquire natural petroleum sources in Southeast Asia and at the same time establish a synthetic fuel industry for the conversion of coal to oil. Actually, the Japanese had begun research on synthetic fuel in the 1920s, only a few years after other countries, such as Germany and Britain, that lacked sources of natural petroleum. They did excellent laboratory research on the coal hydrogenation and Fischer-Tropsch conversion processes, but in their haste to construct large synthetic fuel plants they bypassed the intermediated pilot-plant stage and failed to make a successful transition from small- to large-scale production. Unable to synthesize liquid fuels from coal, they instead derived significant quantities from the technologically simpler coal carbonization and shale oil distillation processes. In the last year of World War II, the Japanese attempted to revive their synthetic fuel industry and entered into an agreement with IG Farben for technical assistance. Germany's defeat ended this final effort. The Japanese synthetic fuel industry presents a good case study of technological failure. It shows that high-quality basic scientific research does not necessarily translate into large-scale technological success. (shrink)

Summary This essay examines the first 30 years of the US Bureau of Mines' synthetic fuel programme during which time Arno C. Fieldner (1881–1966), the Bureau's chief chemist in Washington, DC, established the direction of its fuel research. Fieldner was a world-renowned authority on coal combustion, whose technological style of coal research emphasized the potential applications of the research. He was a keen observer of international developments in coal research and made their study an essential and important part of the (...) Bureau's synthetic liquid fuel programme. International developments, particularly Germany's coal-to-oil or synthetic liquid fuel industry, continued to interest the Bureau during the 1930s–1940s, and, after the Second World War, seven German synthetic fuel scientists came to the USA under Project Paperclip to assist in the construction and operation of the Bureau's coal hydrogenation (liquefaction) and Fischer-Tropsch demonstration plants in Louisiana, Missouri. The two plants were the centrepiece of the Bureau's $87·6 million post-war synthetic fuel programme. During their period of operation from 1949 to 1953 the plants successfully converted American coals to synthetic fuel, and although they were much more efficient than the older German plants, the economics of the conversion became a matter of considerable debate. The Bureau accomplished its objective, however. It had demonstrated the technological feasibility of converting domestic coals to petroleum-like liquids, but the newly elected congress, showing little interest in continuing the programme, ended its financial support and permanently shut down the Missouri operation in 1953. (shrink)

This book contains the collected papers of Alan Donagan on topics in the philosophy of religion. Donagan was respected as a leading figure in American moral philosophy. His untimely death in 1991 prevented him from collecting his philosophical reflections on religion, particularly Christianity, and its relation to ethics and other concerns. This collection, therefore, constitutes the fullest expression of Donagan's thought on Christianity and ethics, in which it is possible to discern the outlines of a coherent, overarching theory. Editor (...) class='Hi'>Anthony Perovich has supplied a useful introduction, which brings Donagan's work into focus and brings out the unifying themes in the essays. (shrink)

Paul Marshall takes extrovertive mystical experience seriously by providing a metaphysical framework inspired by Plotinus and Leibniz that aims to interpret it non-reductively and to explain it persuasively. However praiseworthy Marshall's intentions, his account fails for a variety of reasons, among them an inability to establish convincingly why natural objects appear as transfigured and alive, characteristics frequently encountered in the reports of nature mystics. An alternative approach, rooted in contemporary pan-experientialist philosophy of mind, is able to take extrovertive mysticism equally (...) seriously while accounting more successfully for its pre-eminent features at a less extravagant metaphysical cost. (shrink)

Thomas Aquinas’s theory of self-knowledge stands out among medieval theories for its conceptual sophistication, yet it remains less studied than many other areas of his thought. Here I consider a significant philosophical critique of Aquinas on self-knowledge and respond to it. Anthony Kenny alleges that Aquinas does not sufficiently account for the individuation of thought in the knower. But Kenny’s analysis of how Aquinas individuates thought ironically confuses Aquinas’s account with that of Averroes, whose explanation Aquinas rejected. A closer (...) reading of Aquinas’s texts reveals that intelligible species, not phantasms, individuate thought. Kenny’s central objection to Aquinas’s account of self-knowledge is thus resolved, but I leave open whether Aquinas’s account could be usefully supplemented by modern treatments of self-knowledge. (shrink)

On behalf of the editors of Perspectives in Biology and Medicine, I am pleased to introduce the editors and venue of the Symposium on Synthetic Life: Scientific, Historical, and Ethical Perspectives, which occupies much of the current issue of our journal. We are very pleased that Professors Ute Deichmann, Michel Morange, and Anthony S. Travis planned, organized, and edited the proceedings of the workshop on this topic, held on March 5-6, 2012, at the Jacques Loeb Centre for the History (...) and Philosophy of the Life Sciences and the NIBN at Ben-Gurion University of the Negev in Beer Sheva, Israel.Professor Deichmann has been the founding director of the Centre since it was created in 2007. Although she trained in .. (shrink)

An experimenting society is one in which policy-relevant knowledge is created. It is then critically assessed and communicated in real-life or natural settings, with the aim of discovering new forms of public action to improve the problem-solving capacities of society. This latest volume of the distinguished Policy Studies Review Annual series probes, evaluates, and augments the work of Donald T. Campbell on an experimental societies. A basic assumption of this volume is that Campbell's perspective supplies a useful way to address (...) increasingly complex and seemingly unmanageable problems facing the United States and other postindustrial societies. This volume is also the fourteenth festschrift to be issued by Transaction. The focus is on theoretical as well as practical options for creating an experimenting society. The rationale for this focus is the belief, increasingly -shared in the social science and policy-making communities alike, that researchers are essentially ignorant about how to solve many of the most pressing larger problems of this epoch. This frank recognition of ignorance is a prerequisite of genuine scientific and professional curiosity, without which knowledge gains are next to impossible to achieve, and a'precondition of an experimenting society. Contributors to this original volume include: Steve-Fuller, Duncan MacRae, Jr., Anthony S. Bryk, Robert A. Beauregard, Rita Mae Kelly, Peter Gregware, Burkart Holzner, B. Guy Peters, C. West Churchman, and Ian I. Mitroff. Their multidisciplinary competencies are at once philosophical, methodological, and substantive. They address such questions as: What new or bold policies are available in domains such as education, science, and urban development? In what ways can theoretical knowledge and practical action be fused so as to illuminate or alleviate policy problems? What should be done? Included are excerpts from Campbell's foundational paper "The Experimenting Society," as well as a recent article entitled "Methods for the Experimenting Society," which circulated in unpublished form for many years. An unusual feature of the book is Campbell's responses to those who have addressed his work with candor and intelligence. It will be of interest to policy studies scholars, sociologists, and social scientists. (shrink)